| RomName | Publisher | Year | Country | PlatForm | ROMs |
|---|---|---|---|---|---|
| U-Do | MSX-FAN | 1990 |  |  | 2 |
| U.F.0. | MSXosaure | 2008 |  | | 1 |
| Ultima III - Exodus | Origin Systems | 1987 |  |  | 4 |
| Ultraman | BANDAI | 1984 | | | 1 |
| Universe Unknown | Infinite | 2005 |  | | 3 |
| Urusei Yatsura | Microcabin | 1987 | | | 1 |
| Utopia | DVIK & Joyrex productions / Joyrex | 2008 | | | 1 |
| Uridium | Trilobyte | 2014 | | | 6 |
| Up'n Down | Sega | 1984 | |  | 1 |
| Ulises | Opera Soft | 1989 |  | | 1 |
| Uwol | Imanok | 2016 | | | 1 |
| Ultra Chess | Aackosoft | 1985 | | | 1 |
| Uchūsen Gamma | Juan J. Martinez | 2019 | | | 1 |
| U.F.O | MSXosaure | - | | | 1 |
| Uptak | Cobinee | 2019 | | | 1 |
| Uridium 2 | Artrag | - |  | | 1 |
| Undeadline | T&ESOFT | 1989 | | | 1 |
| Up'n Down | Sega | 1984 | | | 1 |
| Unidentified Flying Object | Cobinee | 2020 | | | 1 |